Jumla Tsarkakakken Halitta Atractylodes Lancea Oil don Kasuwancin Masana'antu Na yau da kullun na Cire Atractylis Oil

pisthorchis viverrini (OV) -induced cholangiocarcinoma (CCA) shine ciwon daji na kowa tsakanin namiji da mace, musamman a Thailand. Binciken da aka yi kwanan nan ya nuna cewa tsantsa ethanol na AL yana da tasiri mai hanawa akan samfurin dabbar CCA da OV ya haifar ba tare da bayyanannen guba ba ta hanyar gudanar da baka na kwanaki 30 bisa ga sakamakon positron emission tomography-computed tomography da namiji hamsters na Siriya.7]. Don bincika tasirin AL rhizome akan motsi na gastrointestinal, an karɓi atropine-, dopamine-, da 5-hydroxytryptamine (5-HT) -a cikin binciken. Sakamakon ya nuna cewa 1 mg/kg tsantsa zai iya danne mahimmancin hana zubar da ciki da ke haifar da dopamine da raguwar motsin ciki ta hanyar allurar intraperitoneal. Tsantsa a cikin maida hankali na 1000 mg / kg zai iya hana atropine-induced ƙananan motsi na hanji, kuma cirewar 500 mg / kg kashi zai iya toshe 5-HT-induced zubar da ciki da ƙananan motsin hanji ya ragu.8]. Bugu da ƙari, AL ya haifar da tasirin maganin ciwon ciki a cikin ƙirar bera ta hanyar rage yawan masu shiga tsakani (watau tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-6), da prostaglandin E2 (PGE2) da haɓaka haɓakar haɓakar epidermal (EGF) da trefoil factor2 (TFF2) [9]. Kwayoyin cututtukan fungal da ke haifar da ƙasa sun rage yawan 30% na gyada [10]. Kwanan nan, an ba da rahoton cewa cuɗanya da gyada, AL kuma na iya kashe cututtukan fungal da ƙasa ke haifarwa ta hanyar hanawa.Fusarium oxysporumgirma [11]. Fitar da man fetur (PE) daga AL ya nuna tasiri mai hanawa akan BGC-823 da SGC-7901 kwayoyin cutar kansa na ciki. PE juzu'in na iya haifar da apoptosis, kama sake zagayowar tantanin halitta, da yuwuwar canje-canjen mitochondrial transmembrane [12]. Wani rahoto na kwanan nan ya nuna cewa MeOH tsantsa na AL zai iya hana samar da nitric oxide (NO) a cikin lipopolysaccharide-stimulated murine macrophage-like RAW264.7 Kwayoyin da kuma haifar da granulocyte-colony stimulating factor (G-CSF) a cikin murine al'ada epithelial MCE301 Kwayoyin. NO shine tsattsauran ra'ayi [13]. Tsarin ethanol na AL yana yin tasiri mai mahimmanci na hanawa akan lipase tare da IC50 9.06 μg/mL a cikin gwajin lipase na ɗan adam, kuma yana nuna tasirin rigakafin kiba akan ƙirar berayen da ke haifar da kiba mai kitse a babban taro na 500 MG. /kg14]. Abubuwan da aka samo daga ruwa daga AL sun nuna aikin antagonistic akan masu karɓar serotonin da kuma tasirin hanawa akan zaɓin 5-HT2A / 2C agonist 1- (2,5-dimethoxy-4-iodophenyl) -2-aminopropane-induced kai-twitch amsa a cikin mice. [15]. Cire ruwa daga AL yana rage yawan guba da ke haifar da triptolide ta hanyar ƙa'ida ta ƙa'idar bayyanar hanta ta CYP3A. A halin yanzu, AL na iya inganta tasirin anti-mai kumburi na triptolide. Waɗannan binciken sun nuna cewa AL na iya hana guba da haɓaka aikin warkewa na triptolide ta hanyar haɗuwa.