Farashin Jumla 100% Pure Forsythiae Fructus man Huta Aromatherapy Eucalyptus globulus

Farashin Jumla 100% Tsaftace Forsythiae Fructus mai Hutun Aromatherapy Eucalyptus globulus Featured Hoto

taƙaitaccen bayanin:

Forsythia suspensa(Thunb.) Wahala. (Family Oleaceae) wani shrub ne na ado, 'ya'yan itatuwan da ake amfani da su a matsayin sanannun TCM "Forsythiae Fructus" (FF) (连翘in Sinanci). Halayen TCM na FF an taƙaita su azaman ɗanɗano mai ɗaci, tare da yanayin sanyi mai laushi da huhu, zuciya ko intestine meridian rarraba (Hukumar Pharmacopoeia na PRC, 2015), waɗannan halayen suna layi ɗaya da halayen anti-mai kumburi TCM, a cewar Chen. da Zhang (2014). A cikin ganyen Shennong, an yi amfani da FF don maganin pyrexia, kumburi, gonorrhea, carbuncle da erysipelas (Cho et al., 2011). Akwai nau'o'i biyu na FF, 'ya'yan itace masu launin kore mai suna "Qingqiao" da kuma launin rawaya cikakke wanda ake kira "Laoqiao". Dukansu biyu suna aiki azaman tushen tushen FF, duk da haka, ana amfani da Qingqiao akai-akai a cikin takaddun takaddun TCM (Jia et al., 2015). Manyan yankunan da ake samarwa na FF sune Hebei, Shaanxi, Shanxi, Shandong, Anhui, Henan, Hubei, Jiangsu (an noma) da Lardunan Sichuan (Hukumar Edita na Flora ta Sin, 1978).

A cikin bugu na 2015 na Pharmacopoeia na kasar Sin, an jera shirye-shiryen magani na kasar Sin 114 dauke da FF, irin su Shuanghuanglian maganin baka, kwamfutar hannu Yinqiao Jiedu, allunan Niuhuang Shangqing, da sauransu (Hukumar Pharmacopoeia na PRC, 2015). Binciken zamani ya bayyana maganin kumburinsa (Kim et al., 2003), antioxidant (CC Chen et al., 1999), antibacterial (Han et al., 2012), anti-cancer (Hu et al., 2007), anti-mai kumburi. -virus (Ko et al., 2005), anti-allergy (Hao et al., 2010), neuroprotective (S. Zhang et al., 2015) tasiri,da dai sauransu.Kodayake ana amfani da 'ya'yan itace kawai azaman TCM, wasu nazarin sun ba da rahoton ilimin phytochemistry da tasirin magunguna na ganye (Ge et al., 2015, Zhang et al., 2015), furanni (Takizawa et al., 1981) da tsaba (Zhang et al. ., 2002).F. supensa. Saboda haka, yanzu mun samar da wani tsari bayyani na samuwa bayanai naF. supensa, gami da amfani na gargajiya, botany, phytochemistry, pharmacology, toxicity, pharmacokinetics da ingancin kula. Har ila yau, ana tattauna hanyoyin da za a bi na bincike a nan gaba.

Snippets na sashe

Amfani na gargajiya

A cikin rubutun ganye na gargajiya na kasar Sin, an rubuta FF a matsayin mai amfani a cikin maganin ƙwanƙwasa bera, scrofula, carbuncle, m ulcer, ciwon gall, zafi da guba (Shennong's herbal, Bencao Chongyuan, Bencao Zhengyi, Zhenglei Bencao). A cewar masana tarihi da yawa, wannan ganyen magani yana da tasiri sosai a kan share zafin tashar zuciya da kuma sakin damshin zafi na saifa da ciki. Har ila yau, yana da magani don maganin stranguria, edema, qi stagnancy da ciwon jini.

Botany

F. supensa(Weeping Forsythia) wani tsiro ne mai ban sha'awa na ado wanda ya fito daga kasar Sin, yana girma zuwa tsayin kusan 3 m (Fig. 1). Yana da ramukan internodes tare da yadawa ko rassan rassa masu launin rawaya-kasa-kasa ko launin toka-kasa-kasa. Ganyayyaki yawanci mai sauƙi ne, amma wani lokacin 3-foliolate. Ganyen ganye suna da kambi, faffadan kambi, ko elliptic-ovate da 2-10 × 1.5-5 cm2 cikin girman tare da zagaye zuwa gindi mai santsi da babban koli. Bangarorin biyu na ganyen kore ne, masu kyalli tare da kaifi ko kauri

Ilimin kimiyya

A halin yanzu, an sami mahalli 237 a cikiF. supensa. ), hudu steroidal (195-198) da 39 wasu mahadi (199-237). Daga cikin su, abubuwa biyu (21-22) an ware su daga furanni naF. supensa, 19 sassa (94-100, 107-111, 115-117, 198, 233-235) an ware daga ganyenF. supensa, guda hudu

Abubuwan da ke hana kumburi

Ayyukan anti-mai kumburi na FF suna goyan bayan tasirin zafi mai zafi (Guo et al., 2015). Kumburi shine amsa ta jiki ga kamuwa da cuta, rashin lafiyan, ko haɓakar sinadarai (Lee et al., 2011). Yana shiga cikin ci gaban cututtuka na yau da kullun, kamar cututtukan fata, allergies, da ciwon daji.da dai sauransu.FF yana ɗaya daga cikin TCM tare da ƙarfin anti-mai kumburi, ana amfani dashi ko'ina ga kumburi na yau da kullun. Ayyukan anti-mai kumburi na FF sune manyan biyar a cikin 81 da aka gwada TCM (70% ethanol

Guba

Har zuwa yanzu, babu wani rahoto kan gubar FF. Adadin gudanarwa na yau da kullun na FF ana ba da shawarar zama 6-15 g (Hukumar Pharmacopoeia na PRC, 2015). Rahotannin da suka dace sun nuna babu wani mummunan guba na ruwa ko cirewar ethanol na ganyenF. supensaa cikin beraye, har ma a kashi na yau da kullun na 61.60 g/kg (Ai et al., 2011, Hou et al., 2016, Li et al., 2013). Han et al. (2017) ya ba da rahoton cewa babu wani mummunan guba na phillyrin (daga ganyenF. Supensa)a cikin NIH mice (18.1 g/kg/day, po, for 14 days) ko a'a

Pharmacokinetics

Li et al. gano metabolites na kashi tara na phillyrin a cikin samfuran fitsari na berayen kuma ya gabatar da hanyoyin da za su iya rayuwa a cikin berayen. An fara sanya Phillyrin hydrolyzed zuwa phillygenin sannan kuma ya canza zuwa wasu metabolites masu rinjaye ta hanyar methylation, demethylation, dehydroxylation da hanyoyin buɗe zobe (Li et al., 2014c). H. Wang et al. (2016) gano 34 Phase I da Phase II metabolites na phillyrin kuma ya nuna cewa hydrolysis, hadawan abu da iskar shaka da sulfation sune manyan.

Kula da inganci

Don sarrafa ingancin FF, Pharmacopoeia na kasar Sin yana ba da shawara ga ilimin halittar jiki, microscopic da ganewar TLC ban da ƙaddarar HPLC. Samfuran FF masu cancanta yakamata su ƙunshi fiye da 0.150% phillyrin (Hukumar Pharmacopoeia na PRC, 2015).

Koyaya, alamar ƙididdigewa ɗaya, phillyrin, da alama bai isa ba don tantance ingancin FF. Kwanan nan, an bincika abubuwan da ke tattare da bioactive daban-daban a cikin FF ta hanyar chromatography na musamman, electrophoresis, MS da hanyoyin NMR, kamar su.

Ƙarshe da hangen nesa na gaba

Bita na yanzu yana taƙaita cikakkun bayanai game da amfani na gargajiya, botany, phytochemistry, tasirin magunguna, guba, pharmacokinetics da kula da ingancin inganci.F. supensa. A cikin rubutun ganya na gargajiya na kasar Sin da Pharmacopoeia na kasar Sin, FF galibi ana amfani da ita don share zafi da kawar da guba. Ya zuwa yanzu, an ware fiye da mahadi 230 kuma an gano su daga wannan ganye. Daga cikin su, lignans da phenylethanoid glycosides ana daukar su azaman halayyar da bioactive.

Ma'anar TCM

Yin: "Yin" yana ɗaya daga cikin ma'auni guda biyu masu gaba da juna na yanayi, bisa ga tsohuwar ginin sararin samaniya na kasar Sin. “Yin” ana siffanta shi da jinkiri, mai laushi, mai ba da juriya, yaduwa, sanyi, rigar ko natsuwa, kuma yana da alaƙa da ruwa, ƙasa, wata, mace da dare.

Qi: A cikin sharuddan acupuncture, "qi" shine "ƙarfin rayuwa". Ita ce tushen duk motsi a cikin jiki, kariya daga mamayewar jiki, tushen duk ayyukan rayuwa, yana ba da riƙe kyallen takarda.

Godiya

Wannan aikin ya sami goyan bayan aikin hadin gwiwa na Binciken Kimiyya na Beijing tare da ilimin digiri na biyu-Bincike na fasaha mai mahimmanci da aikace-aikacen kimanta lafiyar kayan magani na kasar Sin masu guba bisa tsarin sinadarai da halayen zebrafish.

Farashin FOB:US $0.5 - 9,999 / yanki

Min. Yawan oda:Guda 100/Kashi

Ikon bayarwa:10000 Pieces/Perces per month

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Ethnopharmacological dacewar

Forsythiae Fructus (wanda ake kira Lianqiao a Sinanci), 'ya'yan itacenForsythia suspensa(Thunb.) Vahl, ana amfani dashi azaman maganin gargajiya na gama gari a China, Japan da Koriya. Ana amfani dashi a al'ada don magance pyrexia, kumburi,gonorrhea,carbunclekumaerysipelas. Dangane da lokacin girbi daban-daban, ana iya rarraba Forsythiae Fructus zuwa nau'i biyu, wato Qingqiao da Laoqiao. Ana tattara 'ya'yan itatuwa masu launin kore waɗanda suka fara girma a matsayin Qingqiao, yayin da 'ya'yan itatuwa masu launin rawaya waɗanda suka cika cikakke ana tattara su azaman Laoqiao. Dukansu ana amfani da su don amfanin likita. Wannan bita yana nufin samar da taƙaitaccen tsariF. supensa(Forsythia suspensa(Thunb.) Vahl) da kuma bayyana alaƙa tsakanin amfanin gargajiya daayyukan pharmacologicaldon ba da wahayi don bincike na gaba.

kaya da matakai

Duk bayanan da suka dace game da suF. supensaScifinder ne ya bincika kuma ya samo shi daga bayanan kimiyya da suka hada da Springer, Science Direct, Wiley, Pubmed da China Knowledge Resource Integrated (CNKI). An kuma bincika kasidu na gida da littattafai.

Sakamako

Dangane da rubutun ganya na gargajiya na kasar Sin da Pharmacopoeia na kasar Sin, Forsythiae Fructus yana nuna tasirin kawar da zafi da kuma kawar da gubobi a ciki.TCMtakardun magani. A cikin bincike na zamani, an raba fiye da mahadi 230 kuma an gano su dagaF. supensa. 211 Kuma daga cikinsu an keɓe daga 'ya'yan itãce.Lignansda kuma phenylethanoidsglycosidesAna la'akari da halayen halayen wannan ganye, kamar forsythiaside, phillyrin,rutinda phillygenin. Sun nuna anti-inflammatory, antioxidant, antibacterial, anti-virus, anti-cancer da anti-allergy effects,da dai sauransu.A halin yanzu, babu wani rahoto game da guba na Forsythiae Fructus, duk da ɗan ƙaramin guba na forsythiaside da aka ruwaito a cikin wallafe-wallafen gida. Idan aka kwatanta da Laoqiao, Qingqiao ya ƙunshi manyan matakan forsythiaside, forsythoside C, cornoside,rutin, phillyrin,galic acidkumachlorogenic acidda ƙananan matakan rengyol,βGlucose da S-supensasidemethyl ether.

Kammalawa

Ayyukan tsabtace zafi na Forsythiae Fructus sun dogara ne akan anti-mai kumburi da kaddarorin antioxidant na lignans da phenylethanoid.glycosides. Detoxifying effects dangana ga antibacterial, antiviral da anti-cancer ayyukan Forsythiae Fructus. Kuma halayen magungunan gargajiya na kasar Sin (TCM) na Forsythiae Fructus (daci, yanayin sanyi da huhu) sun goyi bayan tasirinsa mai ƙarfi na hana kumburi. Bugu da kari, da ban mamaki anti-mai kumburi daantioxidant capacitiesna Forsythiae Fructus yana ba da gudummawa ga rigakafin ciwon daji daneuroprotectiveayyuka. Mafi girman adadin lignans da phenylethanoid glycosides a cikin Qingqiao fiye da Laoqiao na iya yin bayanin mafi kyawun ikon antioxidant na Qingqiao da yawan amfani da Qingqiao akai-akai.TCMtakardun magani. Don bincike na gaba, ƙariin vivogwaje-gwaje da nazarin asibiti ana ƙarfafa su don ƙara bayyana alaƙa tsakanin amfani da al'ada da aikace-aikacen zamani. Dangane da Qingqiao da Laoqiao, ya zama dole a bambanta su ta kowane nau'i na sarrafa inganci, kuma ya kamata a kwatanta nau'ikan sinadarai da tasirin asibiti tsakanin su.